Dysport© (abobotulinumtoxinA)

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Dysport® is a prescription medicine that is injected into muscles and used to treat:

  • increased muscle stiffness in elbow, wrist, and finger muscles in adults with upper limb spasticity
  • cervical dystonia (CD) in adults

It is not known whether Dysport® is safe or effective in children under 18 years old or for the treatment of other types of muscle spasms.

Dysport® for the treatment of adults with upper limb spasticity (ULS)

Dysport® has been approved in the US market since 2009 for the use in adults with cervical dystonia. In 2015, Dysport® received another indication for use in adults with upper limb spasticity.

How ULS occurs

ULS occurs when the nerve cells that carry messages from your brain to different parts of your body are damaged. When this happens, the affected muscles in the upper limbs receive the wrong signals. This can cause your muscles to contract or tense up, leading to severe stiffness and tightness in your elbow, wrist, and finger muscles.

Upper limb spasticity in adults can take many forms. These images show the condition in wrist, elbow, and fingers of an adult.

How Dysport® works in adults with ULS

Dysport® is a type of prescription medicine that is a botulinum toxin type A that is injected into the muscles of adults with ULS. Dysport® works by helping to temporarily block signals from the nerves that tell the affected muscles to contract or tighten. This can help reduce muscle stiffness in the elbow, wrist, and finger muscles in people with ULS.

In a clinical study, Dysport® significantly reduced stiffness in the elbow, wrist, and finger muscles at Week 4. For some people, improvement was seen 1 week after treatment with Dysport®.

Approximately 3 out of 4 patients had a response to treatment at Week 4 as measured by a reduction in stiffness in the elbow, wrist, or finger muscles

Common side effects

The most common side effects of Dysport® in adults with upper limb spasticity include urinary tract infection, muscle weakness, musculoskeletal pain, fall, depression, stuffy or runny nose and sore throat, and dizziness.

*You may be eligible if your Dysport® therapy is covered by a commercial insurance company and you are not covered by a federal- or state-funded insurance program. Additional eligibility rules apply and can be found at IpsenCares.com.

Important Safety Information for Dysport®

Dysport® (abobotulinumtoxinA) may cause serious side effects that can be life threatening, including problems breathing or swallowing, and spread of toxin effects. These problems can happen within hours, or days to weeks after an injection of Dysport®. Call your doctor or get medical help right away if you have any of these problems after treatment with Dysport®:

  • Problems swallowing, speaking, or breathing after an injection of Dysport® if the muscles that you use to breathe or swallow become weak. If these problems are severe, death can happen as a complication. People with certain breathing problems may need to use muscles in their necks to help them breathe and may be at greater risk for serious breathing problems with Dysport®.
  • Swallowing problems may last for several weeks; you may need a feeding tube to receive food or water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or breathing problems before receiving Dysport® have the highest risk of getting these problems.

Spread of toxin effects. In some cases, the effects of botulinum toxin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. The symptoms of botulism include: loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, or trouble swallowing. These problems could make it unsafe for you to drive a car or do other dangerous activities.

Do not take Dysport® if you are allergic to Dysport® or any of the ingredients in Dysport® (See Medication Guide for ingredients), or are allergic to cow’s milk protein; had an allergic reaction to any other botulinum toxin product, such as Myobloc® (rimabotulinumtoxinB), Botox® (onabotulinumtoxinA), or Xeomin® (incobotulinumtoxinA); or have a skin infection at the planned injection site.

Before you take Dysport®, tell your doctor about all your medical conditions, including if you have a disease that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou Gehrig’s disease], myasthenia gravis, or Lambert-Eaton syndrome), as you may be at increased risk of serious side effects, including difficulty swallowing or breathing.

Before you take Dysport®, tell your doctor if you have or have had any of the following: a side effect from any botulinum toxin in the past; breathing problems such as asthma or emphysema; swallowing problems; bleeding problems; diabetes; and slow heartbeat, or other problems with your heart rate or rhythm.

Tell your doctor if you have plans to have surgery, had surgery on your face, have weakness of your forehead muscles (such as trouble raising your eyebrows), have drooping eyelids, or have any other change in the way your face normally looks.

Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding or planning to breast-feed. It is not known if Dysport® can harm your unborn baby. It is not known if Dysport® passes into breast milk.

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal products. Using Dysport® with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your doctor that you have received Dysport® in the past.

Especially tell your doctor if you have received injections of botulinum toxin in the last four months or in the past. Be sure your doctor knows exactly which product you received such as Myobloc® (rimabotulinumtoxinB), Botox® (onabotulinumtoxinA), or Xeomin® (incobotulinumtoxinA); have recently received an antibiotic by injection; take muscle relaxants; take an allergy or cold medicine; or take a sleep medicine.

Most common side effects of Dysport® in people with upper limb spasticity include: urinary tract infection, muscle weakness, musculoskeletal pain, fall, depression, stuffy or runny nose and sore throat, and dizziness.

Most common side effects of Dysport® in people with cervical dystonia include: muscle weakness, dry mouth, feeling of tiredness, neck pain or muscle pain, problems speaking, eye problems, difficulty swallowing, injection site pain, and headache.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Dysport®. For more information, ask your doctor or pharmacist.

What is Dysport®?

Dysport® is a prescription medicine that is injected into muscles and used to treat:

  • increased muscle stiffness in elbow, wrist, and finger muscles in adults with upper limb spasticity
  • cervical dystonia (CD) in adults

It is not known whether Dysport® is safe or effective in children under 18 years old or for the treatment of other types of muscle spasms.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Click here to view Full Prescribing Information including Boxed Warning or Medication Guide.

Botox®, Xeomin®, and Myobloc® are registered trademarks of their respective owners.

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